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Research & Development | Core Strengths

Commitment to Science

Baxter’s BioScience business applies a unique combination of expertise in medical devices, pharmaceuticals, and biotechnology to create products that improve patient care worldwide.

Baxter is investigating uses within its immunoglobulin portfolio in neurology and immunology, for disorders such as Alzheimer’s disease and multifocal motor neuropathy (MMN).

Baxter’s BioScience business, in conjunction with Halozyme Therapeutics, is investigating developing new delivery technology for subcutaneous administration of IGIV.

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Leading Quality and Safety Systems

Baxter is a fully integrated business that complies with regulatory requirements to ensure product safety, efficacy, and quality. This helps assure high quality products from the plasma donors to patients who benefit from our therapies.

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Baxter Global Pathogen Safety Group

The Baxter Global Pathogen Safety Group is an established leader regarding the safety of plasma-derived therapeutics. The group is dedicated and focused on reducing the risk to Baxter products from current and emerging pathogens.

Highlights

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Manufacturing Expertise

Baxter has a cutting edge biologics manufacturing expertise in plasma fractionation, recombinant protein production, and proprietary Vero cell vaccine production technology. Baxter’s plasma fractionation facilities strive to increase efficiency and support greater product yields, to ensure that more patients have access to its therapies. The company’s experience in plasma fractionation has also resulted in the development of reliable and innovative therapies for the treatment of various chronic conditions.

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Understanding the Functional Antibodies for Improved Care

Advancing Virus Neutralization Capacity of IGIV Lots

While immunoglobulin products have been used to treat primary immunodeficiency (PI) patients for decades, the antibody titers needed to protect PI against certain pathogens are still ill defined. Infrequent virus infections that still occur in PI despite IGIV substitution therapy suggest that a better understanding of the functional antiviral efficacy, ie, the virus neutralization capacity, of specific IGIV lots might be beneficial, particularly given the lack of conventional therapeutic alternatives for the treatment of virus infections.

A better understanding of the functional antibody repertoire of individual IGIV lots may allow for more

Specific Areas of Study

Emerging Viruses (West Nile Virus)1

Finding

Significant differences depending on plasma donor

Geography

Neutralising antibody titers (NT) in US IGIV significant, in EU IGIV low/none (1)

Demographics

Emerging neutralising antibody titers (ENT) of IGIV produced from US Source plasma are significantly higher than those produced from US Recovered plasma

Endemic (Known) Viruses: B19 and Hepatitis A1

Finding

  • Depending on plasma donor demographics, significantly
  • different B19V antibody titers were found
  • Depending on the plasma donor residency (EU/US)
    • HAV ELISA titers vary significantly (EU is higher)
    • HAV neutralization titers are similar
    • Poor correlation between titers determined by ELISA/neutralization assay

Variable (Fluctuating Viruses): Echo and Enterovirus1

Finding

Significant differences depending on plasma donor

Geography

NT against E 9/11 in US IGIV significantly higher than in EU IGIV

Demographics

NT against E 11/13/30 of IGIV produced from Source plasma are significantly higher than those produced from Recovered plasma

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References

RESEARCH & DEVELOPMENT

ADDITIONAL RESOURCES

Baxter BioScience Grants Program

Baxter BioScience Grants Program

movie

For more information on subcutaneous injection, please click here to view the video.

Clinical Trials